Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives
نویسندگان
چکیده
منابع مشابه
Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives
We have developed a series of aminoacetylenic isoindoline-1,3-dione compounds and showed their anti-inflammatory activities by reducing carrageenan-induced rat paw edema and modulating proinflammatory and anti-inflammatory cytokines. In the present study and due to efficacy reasons, we are exploring only two of these compounds, namely, ZM4 and ZM5, to reveal their analgesic activity and toxicit...
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Three mononuclear oxovanadium complexes [VO(Hbid)(CF3PIP)] (1) (Hbid=(E)-2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione, CF3PIP=2-(2-trifluoromethyl phenyl)imidazole[4,5-f][1,10] phenanthroline), [VO(Hbid)(m-CF3PIP)]; (2) (m-CF3PIP=2-(3-trifluoromethyl phenyl)imidazole [4, 5-f][1,10]phenanthroline) and [VO(Hbid)(p-CF3PIP)]; (3) (p-CF3PIP=2-(4-trifluoromethyl phenyl) imidazole[4,5-f][1,10]ph...
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In the course of our studies of silicon-containing anti-cancer compounds, the title compound, C(13)H(17)NO(2)Si, was synthesized. The geometrical parameters including the geometry about the Si atom are typical. The mol-ecules form dimers via a weak C-H⋯O inter-action described by the graph set R(2) (2)(10). The dimers are assembled in rows stacked in the crystallographic b-axis direction via π-...
متن کامل2-(3-Bromopropyl)isoindoline-1,3-dione
In the title compound, C(11)H(10)BrNO(2), the dihedral angle between the five- and six-membered rings of the phthalamide system is 1.00 (16)°. There are no significant inter-molecular inter-ations except for van der Waals contacts.
متن کامل2-[3-(Methyldiphenylsilyl)propyl]isoindoline-1,3-dione
In the title compound, C(24)H(23)NO(2)Si, the dihedral angle between the planes of the phenyl rings attached to the Si atom is 80.78 (10)°. In the crystal, the mol-ecules form sheets lying perpendicular to [101] via C-H⋯O inter-actions. These sheets are stacked and linked in a three-dimensional framework by additional C-H⋯O inter-actions in the [10] direction.
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ژورنال
عنوان ژورنال: ISRN Pharmacology
سال: 2012
ISSN: 2090-5173
DOI: 10.5402/2012/657472